Reprogramming somatic cells to their embryonic state
نویسندگان
چکیده
منابع مشابه
Reprogramming mammalian somatic cells.
Somatic cell nuclear transfer (SCNT), the technique commonly known as cloning, permits transformation of a somatic cell into an undifferentiated zygote with the potential to develop into a newborn animal (i.e., a clone). In somatic cells, chromatin is programmed to repress most genes and express some, depending on the tissue. It is evident that the enucleated oocyte provides the environment in ...
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Nucleostemin (NS) is a nucleolar GTP-binding protein that was first identified in neural stem cells, the functions of which remain poorly understood. Here, we report that NS is required for mouse embryogenesis to reach blastulation, maintenance of embryonic stem cell (ESC) self-renewal, and mammary epithelial cell (MEC) reprogramming to induced pluripotent stem (iPS) cells. Ectopic NS also coop...
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The process of 'cell reprogramming' can be achieved by somatic cell nuclear transfer, cell fusion with embryonic stem cells, exposure to stem cell extracts, or by inducing pluripotentcy mediated by defined factors giving rise to what are termed induced pluripotent stem cells. More recently, the fate of a somatic cell can be directly induced to uptake other cell fates, termed lineage-specific re...
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Stem cells are the body’s ‘master’ cells, they are pluripotent cells, and in theory, they can potentially be differentiated to any tissue-type in the body. Until today, stem cells have been derived from the totipotent cells of the inner cell mass (ICM) of mouse and human blastocysts. The ability of a differentiated somatic cell to switch into a pluripotent cell has puzzled researchers for sever...
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Genomic reprogramming of primordial germ cells (PGCs), which includes genome-wide demethylation, prevents aberrant epigenetic modifications from being transmitted to subsequent generations. This process also ensures that homologous chromosomes first acquire an identical epigenetic status before an appropriate switch in the imprintable loci in the female and male germ lines. Embryonic germ (EG) ...
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ژورنال
عنوان ژورنال: HFSP Journal
سال: 2007
ISSN: 1955-2068
DOI: 10.2976/1.2757614